Preparation of alginate–chitosan–cyclodextrin micro- and nanoparticles loaded with anti-tuberculosis compounds

• Albert Ivancic,
• Fliur Macaev,
• Fatma Aksakal,
• Veaceslav Boldescu,
• Serghei Pogrebnoi and
• Gheorghe Duca

Beilstein J. Nanotechnol. 2016, 7, 1208–1218, doi:10.3762/bjnano.7.112

• ; quaternary system; sodium alginate; Introduction Tuberculosis, together with HIV infection, is a leading cause of death with 1.5 million deaths in 2014 worldwide [1]. The biggest challenges regarding a successful treatment of tuberculosis infections are the necessary high dosages and various side effects of

• than the DGI of the 1:100 control. Preparation of the microparticulate systems The quaternary system: ISN–β-cyclodextrin–alginate–chitosan (system 1) was obtained using kneading, the mass ratio of components was 1:2.36:4:4. At the first stage, the binary system ISN–β-cyclodextrin was obtained by